Targeting BCL-XL-mediated apoptotic resistance in lung cancer: in silico and in vitro identification of bioactive inhibitors from Ailanthus excelsa chloroform extract

Introduction

Lung cancer is one of the most prominent causes of cancer-related death worldwide, primarily driven by apoptosis resistance linked to the overexpression of antiapoptotic proteins. BCL-XL plays a regulatory function in cellular apoptosis, making it a critical therapeutic target in cancer treatment. In this study, we explored the potential therapeutic effects of phytocompounds isolated from leaves of Ailanthus excelsa to inhibit BCL-XL using an integrated approach combining in silico and in vitro methods.