bioRxiv : the preprint server for biology
Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph
By Watanabe R and Lee EB.
Abstract
Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolved the canonical CTE Type I structure and a previously unreported CTE Type I-like structure with a shifted protofilament interface at 2.78 and 2.96 Å, respectively. Mapping particle-state assignments back onto the original micrographs showed that the CTE Type I and CTE Type I-like packing states can occupy locally contiguous regions within the same fibrils. These findings identify an interface-shifted CTE Type I-like structure and support its local coexistence with CTE Type I within individual fibrils.
Keywords
- chronic traumatic encephalopathy
- cryo-electron microscopy
- filament polymorphism
- protofilament interface
- tau
Source
This is a preprint: it has not been peer reviewed yet, and its findings may change.
Published in bioRxiv : the preprint server for biology. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.
