[Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial].

To observe the clinical efficacy of moxibustion combined with Jianpi Wenshen formula in treating cancer-related anorexia of spleen-kidney yang deficiency. A total of 80 patients with cancer-related anorexia of spleen-kidney yang deficiency were randomized into an observation group and a control group, with 40 cases in each group.Jianpi Wenshen formula was given orally in the control group. On the basis of the treatment in the control group, moxibustion was applied at bilateral Zusanli (ST36), Neiguan (PC6) and Zhongwan (CV12), Guanyuan (CV4), Mingmen (GV4) in the observation group, once daily for the first 15 days, then once every other day. Both groups were treated for 4 weeks. The scores of appetite, Karnofsky performance status (KPS), nutritional risk screening 2002 (NRS-2002), and patient-generated subjective global assessment (PG-SGA), as well as the serum levels of interferon-γ (IFN-γ) and C-reactive protein (CRP)were observed before and after treatment, and the clinical efficacy was evaluated after treatment in the two groups. After treatment, the scores of appetite, NRS-2002, PG-SGA, and the serum levels of IFN-γ and CRP were decreased compared with those before treatment in the two groups (P<0.001, P<0.05, P<0.01), and the above indexes in the observation group were lower than those in the control group (P<0.05, P<0.001); the KPS scores were increased in the two groups compared with those before treatment (P<0.001, P<0.05), and the KPS score in the observation group was higher than that in the control group (P<0.001). The marked response rate was 57.5% (23/40) in the observation group, which was higher than 30.0% (12/40) in the control group (P<0.05). Moxibustion combined with Jianpi Wenshen formula can effectively improve appetite and overall status, and reduce the levels of IFN-γ and CRP in patients with cancer-related anorexia of spleen-kidney yang deficiency. 目的：观察艾灸联合健脾温肾方治疗脾肾阳虚型癌性厌食的临床疗效。 方法：将80例脾肾阳虚型癌性厌食患者随机分为观察组和对照组，各40例。对照组给予健脾温肾方治疗；观察组在对照组基础上于双侧足三里、内关和中脘、关元、命门施艾灸治疗，前15 d每日1次，后改为隔日1次。两组均治疗4周。分别于治疗前后观察两组患者食欲、Karnofsky功能状态（KPS）、营养风险筛查2002（NRS-2002）、患者主观整体营养（PG-SGA）评分和血清干扰素-γ（IFN-γ）、C反应蛋白（CRP）含量，并于治疗后评定两组临床疗效。 结果：治疗后，两组患者食欲、NRS-2002、PG-SGA评分和血清IFN-γ、CRP含量均较治疗前降低（P<0.001，P<0.05，P<0.01），且观察组低于对照组（P<0.05，P<0.001）；两组患者KPS评分均较治疗前升高（P<0.001，P<0.05），且观察组高于对照组（P<0.001）。观察组显效率为57.5%（23/40），高于对照组的30.0%（12/40，P<0.05）。 结论：艾灸联合健脾温肾方可有效改善脾肾阳虚型癌性厌食患者食欲和整体状态，降低血清IFN-γ、CRP含量。.