Cancer-Associated Fibroblast-Derived Molecular Cues Driving Epithelial–Mesenchymal Transition and Invasion in Oral Squamous Cell Carcinoma: A Systematic Review

Introduction

Local invasion and nodal metastasis are the main determinants of poor survival in “oral squamous cell carcinoma (OSCC). Cancer-associated fibroblasts (CAFs)” are increasingly recognized as instructive stromal cells that confer epithelial-mesenchymal plasticity to tumor cells, but the molecular cues involved have not been systematically evaluated for OSCC.