Association of Salivary Pepsin with Systemic Inflammatory Biomarkers and Laryngeal Disease Severity in Patients with Laryngopharyngeal Reflux–Associated Chronic Laryngitis

Background

Laryngopharyngeal reflux (LPR) is clinically heterogeneous and symptoms and/or laryngoscopic signs alone have limited specificity. While salivary pepsin is a non-invasive measure of gastric-content exposure, its association with systemic inflammation and severity of laryngeal disease is not well described.