JK Science
Renal-Limited Sarcoidosis Presenting as Acute Kidney Injury: A Biopsy-Guided Diagnostic Challenge
By Ranjana S. Ranade and Basavaraj Sajjan.
Abstract
We report a case of a 72-year-old female presenting with vomiting and generalized weakness for two weeks. Laboratory evaluation revealed severe acute kidney injury with a serum creatinine of 12.4 mg/dL. Renal biopsy demonstrated granulomatous interstitial nephritis with non-caseating granulomas and occasional Schaumann bodies. Extensive evaluation excluded tuberculosis, drug-induced injury, infections, and autoimmune diseases. High-resolution CT chest showed no pulmonary involvement. In view of characteristic histomorphology and markedly elevated serum ACE levels, a diagnosis of renal-limited sarcoidosis was made. Treatment with oral prednisolone (0.5 mg/kg/day) resulted in significant improvement in renal function, with creatinine declining to 1.4 mg/dL on follow-up.
Keywords
- Sarcoidosis and Beryllium Toxicity Research
- Open access
Source
Published in JK Science. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.
