Циркулирующие биомаркеры окислительного стресса и внеклеточные нуклеиновые кислоты как потенциальные маркеры состоятельности рубца на матке: биологическое обоснование и план исследований

Relevance: A scarred uterus is among the commonest conditions in obstetrics, and its failure during a trial of labor remains rare and hard to foresee. Prediction rests on ultrasound of the lower uterine segment and clinical history. Segment thickness discriminates rupture risk well, yet no circulating molecular marker is used in practice, and ultrasound reports the scar’s geometry, not the biology of one about to give way. The study aimed to build a testable biological case for two families of blood-borne candidate markers of uterine scar integrity—oxidative stress and extracellular nucleic acids—and to set out a program for evaluating them. Materials and Methods: Narrative, hypothesis-generating review. We searched PubMed, Scopus, and Web of Science for evidence over the past five years on uterine scar healing and dehiscence, oxidative-stress biomarkers in pregnancy, and cell-free nucleic acids as tissue-injury markers. No primary study has measured these markers as predictors of scar dehiscence, so candidates were drawn from adjacent, established literatures.