Eureka Journal of Health Sciences & Medical Innovation
Dissociation of cardiospecific biomarkers and left ventricular systolic function in patients with acute leukemias
By Zokirova M. B. and Iskandarova Sh. T..
Abstract
Cardiovascular complications are a significant factor limiting the administration of antitumor therapy in patients with acute leukemias. Traditional assessment of cardiotoxicity is predominantly based on the dynamics of left ventricular ejection fraction (LVEF); however, functional myocardial changes may develop later than biochemical signs of damage. Elevation of cardiac troponin and NT-proBNP with preserved LVEF potentially reflects a subclinical stage of myocardial injury and may be used for earlier risk stratification.
Keywords
- Chemotherapy-induced cardiotoxicity and mitigation
- acute leukemia
- cardiotoxicity
- left ventricular systolic function
- left ventricular ejection fraction
- cardiac troponin
- NT-proBNP
- subclinical myocardial injury
- risk stratification
- cardio-oncology
- Open access
Source
Published in Eureka Journal of Health Sciences & Medical Innovation. The abstract is shown as published and remains the work of its authors; read the full article at the source.
