Short-Term Effects of Electronic Cigarette Use on Lung Function: A Meta-Analysis of Randomized Controlled Trials

Purpose

This meta-analysis aimed to systematically evaluate the short-term effects of electronic cigarette use on respiratory function through evidence synthesis of randomized controlled trials. Research design, data and methodology: Systematic searches were conducted in PubMed, Medline, Embase, and Web of Science databases for studies published between January 2006 and January 2024. Randomized controlled trials assessing e-cigarette effects on lung function parameters (FEV1, FVC, FEV1/FVC, FeNO) were included. Nine studies comprising 677 participants met the inclusion criteria. A random effects model was applied to calculate standardized mean differences (SMD) with 95% confidence intervals. Heterogeneity was evaluated using I² statistics and publication bias was assessed via Egger's test.