Journal of Advances in Medicine and Medical Research
Post-treatment Dermal Thickness after Repeated Autologous Albumin Platelet-rich Fibrin Versus Hyaluronic Acid at the Nasolabial Fold: An Age-adjusted Ultrasound Comparative Study
By Nina Hassani, Patrick Micheels, Nizar Kheireddine and 1 others.
Abstract
Background
Nasolabial-fold correction can be achieved with hyaluronic acid (HA) fillers or autologous platelet-rich fibrin-based materials, but post-treatment tissue thickness may reflect different structural effects.
Aims
To determine whether repeated autologous albumin platelet-rich fibrin treatment is associated with a stronger sonographic dermal-thickness signal than repeated hyaluronic acid treatment at the nasolabial fold after accounting for age. Study Design: Retrospective cross-sectional comparative study. Place and Duration of Study: Cardiomed Jura, Courrendlin, Switzerland. The albumin platelet-rich fibrin cohort received three sessions over approximately one year; ultrasound was performed three months after the third session. The hyaluronic acid cohort had received at least three treatments during the preceding three years, with imaging at least three months after the latest treatment. Methodology: Twenty women were included (10 per group). High-frequency ultrasound assessed post-treatment dermal thickness. Exact Mann-Whitney testing, within-group Spearman correlations, and an exploratory age-adjusted linear model were used.
