Open access journal
Chronic Haemolytic–inflammatory Activation Persists beyond Clinical Crisis in Adults with Sickle Cell Anaemia: A Comparative Cross-sectional Study
By Adeyanju Oluwaseyi Adeteju, Festus Olatubosun Amusan, Beatrice Ebun Adesina and 5 others.
Abstract
Background
Sickle cell anaemia is characterised by chronic haemolysis and inflammation. Whether these processes persist during clinically stable periods or are mainly associated with painful crises remains unclear in the local literature.
Objective
To compare lactate dehydrogenase (LDH) and C-reactive protein (CRP), markers of haemolysis and inflammation, among adults with sickle cell anaemia in steady state, those admitted with a painful crisis, and healthy controls.
