Inherited and Acquired Thrombophilia in Patients with Previous Thrombosis: An Integrated Analysis of Thrombophilic Profiles and Their Combined Associations

Background

Thrombosis is a multifactorial condition in which inherited thrombophilic abnormalities, acquired haemostatic disturbances, and other clinical factors may coexist and contribute to thrombotic susceptibility. Because multiple abnormalities can occur within the same individual, their relative and combined associations with previous thrombosis require integrated evaluation, particularly when inherited thrombophilia and antiphospholipid antibody profiles are considered together.