International Blood Research & Reviews
An Integrated Haemolysis–Inflammation–Haemostasis Signature across Clinical States of Sickle Cell Anaemia: A Comparative Biomarker Study
By Oluwaseyi Adeteju Adeyanju, Richard Peter Akpan, Mitchelle Akanbi and 3 others.
Abstract
Background
Sickle cell anaemia involves interconnected haemolytic, inflammatory, and haemostatic disturbances that may persist beyond overt crisis.
Aims
To compare a combined five-parameter profile—lactate dehydrogenase (LDH), C-reactive protein (CRP), prothrombin time (PT), international normalised ratio (INR), and activated partial thromboplastin time (referred to locally as PTTK)—across patients with sickle cell anaemia in steady state, patients in crisis, and healthy controls, and to consider its relevance to transfusion practice.
