International Blood Research & Reviews
Trimester-specific Variations in Prothrombin Time, Activated Partial Thromboplastin Time, and Platelet Count among Pregnant Women at Adeoyo Maternity Teaching Hospital, Oyo State, Nigeria
By Abibat Opeyemi Badmos, Beatrice Ebun Adesina, Adesola Helen Oniye and 1 others.
Abstract
Background
Pregnancy is associated with physiological changes in haemostasis that may vary across gestation.
Aims
To assess prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet count across the three trimesters of pregnancy and compare these parameters with those of non-pregnant controls among women attending Adeoyo Maternity Teaching Hospital (AMTH), Oyo State, Nigeria, and to contribute towards trimester-specific reference values for antenatal coagulation monitoring. Study Design: Cross-sectional, comparative study. Place and Duration of Study: Antenatal clinic, Adeoyo Maternity Teaching Hospital (AMTH), Ibadan, Oyo State, Nigeria, in collaboration with the Department of Medical Laboratory Science, Lead City University, Ibadan. Methodology: 230 women were studied: 180 pregnant women (60 each in the first, second, and third trimesters) and 50 non-pregnant controls of reproductive age. Ethical approval was obtained from the Ethics Review Committee, Ministry of Health, Oyo State, and written informed consent was obtained from all participants. Venous blood was collected into sodium citrate tubes for PT and aPTT (manual clotting method) and EDTA tubes for platelet count (Sysmex automated haematology analyser). Data were analysed by one-way ANOVA with post hoc Tukey comparison; significance was set at p < 0.05.
