Abstract / Summary
BackgroundPeripheral artery disease (PAD), particularly chronic limb-threatening ischemia (CLTI), is associated with a high risk of limb loss and significant morbidity.Endovascular therapy (ET) has emerged as a minimally invasive alternative to surgical revascularization, especially in high-risk patients and those with comorbidities.This study aims to evaluate the effectiveness of ET in achieving limb salvage in a Southern Indian population. Materials and methodsThis retrospective observational study was conducted at a tertiary vascular care center and included 142 patients with symptomatic PAD who underwent endovascular intervention between July 2023 and June 2025.Clinical severity and lesion complexity were assessed using the Rutherford classification and the TransAtlantic Inter-Society Consensus II (TASC II) classification, respectively.The primary endpoint was limb salvage at one year, defined as freedom from major amputation.Secondary endpoints included technical success, restenosis, and procedure-related complications. ResultsThe study population was predominantly male (87.3%) with a mean age of 61.11 ± 12.90 years.Most patients (78.1%) presented with CLTI.Technical success was achieved in 87.3% of procedures.At one-year follow-up, limb salvage was achieved in 95.8% of patients, with major amputation occurring in 4.2% and minor amputation in 9.1%.Restenosis was observed in 14.7% of cases.Procedure-related complications were infrequent and mostly minor, with one all-cause death during follow-up. ConclusionsET is a safe and effective modality for limb salvage in PAD patients, particularly in populations with a high prevalence of diabetes and advanced disease at presentation.High limb salvage rates can be achieved even in cohorts predominantly comprising patients with CLTI, supporting an endovascular-first approach in appropriately selected patients.