Cureus
Drug-Disease Interactions Causing Hemorrhagic Cardiac Tamponade
By Brian Torres-Mercado, Xavier Delgado-Lopez, Joseph Maldonado-Suarez and 2 others.
Abstract
Hemorrhagic tamponade in severe hypothyroidism is an uncommon presentation that warrants evaluation for superimposed pathology.We present the case of a 57-year-old man with nonischemic cardiomyopathy, chronic amiodarone therapy, and atrial fibrillation on apixaban who developed advanced myxedema, complicated by a large hemorrhagic pericardial effusion and cardiac tamponade.This case highlights a rare but life-threatening convergence of amiodarone-induced severe hypothyroidism and potentiated anticoagulation, culminating in hemorrhagic tamponade.Recognition of drug-disease interactions is critical in anticoagulated patients with endocrine dysfunction who present with rapidly recurrent pericardial effusion.
Keywords
- Pericarditis and Cardiac Tamponade
- drug-disease interactions
- cardiac tamponade
- adverse drug reactions
- bleeding complications
- Open access
Source
Published in Cureus. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.
