Abstract / Summary
Orthostatic hypotension (OH) following spinal cord injury (SCI) can significantly limit functional recovery by impairing participation in rehabilitation.Non-pharmacological techniques and pharmacological therapies, including fludrocortisone and midodrine, are conventionally used to manage OH.However, when these measures fail, atomoxetine has demonstrated benefit in other neurogenic OH populations.Evidence regarding the efficacy of this selective norepinephrine reuptake inhibitor is limited in neurogenic OH related to SCI.In this case series, we describe five patients with SCI who had symptomatic OH that did not respond to conventional pharmacological agents but showed clinical improvement with atomoxetine (dose range of 10 mg to 23 mg).Hence, atomoxetine can be considered a potential alternative therapeutic option for OH related to SCI in patients with OH refractory to conventional management.