Abstract / Summary
The biomechanical properties of the human aorta play a key role in cardiovascular function and disease, yet their population-wide trends and variations remain largely unknown. To fill this crucial gap, we quantified variations in aortic size, stiffness and stresses across 57,434 individuals from the UK Biobank using two-dimensional cine MR imaging and a combined deep-learning, probabilistic and biomechanical modelling framework. Aortic diameter and distensibility (inverse of stiffness) were calculated for the ascending and descending aorta, and their conditional distributions were characterised as a function of age, sex, body size and blood pressure. These observations were integrated with ex-vivo tissue mechanics to infer stress distributions across the aortic wall and the associated uncertainty. Our analysis revealed several new relationships. Larger aortas were found to be stiffer, and greater body size (height and/or weight) was associated with larger aortas with no change in stiffness. Aortic distensibility was negatively associated with systolic, but not diastolic, blood pressure. Apparent sex differences in aortic size were substantially reduced after accounting for body size. Importantly, the maximum stress was found to depend not only on aortic size, as previously thought, but also on distensibility, with lower distensibility associated with higher stresses. The results provide first-of-their-kind population-scale reference distributions for human aortic stiffness, which will improve the personalisation of computational models and digital twins. The correlation between stress and distensibility strongly supports progressing beyond the current diameter-based criteria (based on the law of Laplace) and for the inclusion of stiffness in the clinical risk assessment of aortic diseases. Overall, this study forms the foundation for personalised quantitative medicine and biomechanically informed risk stratification of aortic aneurysms and dissections.