Abstract / Summary
Background. Quantitative optical coherence tomography (OCT) measurements are essential for retinal disease monitoring, yet leading vendors store acquisition data in undocumented proprietary formats or encode measurements exclusively in private DICOM tags inaccessible to open systems. Methods. We present Transducin, an open-source Python library that reverse- engineers, through systematic binary analysis cross referenced against DICOM exported metadata from the same studies, the undocumented Optopol REVO FC130 and REVO 60 .OPT binary format and extracts quantitative measurements from Zeiss Cirrus HD-OCT 500 private DICOM tags, generating TID 1500 Structured Reports with SNOMED-CT coded findings for both platforms. A novel finding is that a scan-geometry parameter recorded by the OCT device (OCTPARAMS tag 23, the horizontal position of the foveal or disc reflex relative to scan center) encodes ocular laterality through its arithmetic sign (an anatomical consequence of the fovea's nasal position relative to the optic disc) enabling automated laterality inference that requires no operator data entry or filename convention. Results. The validation corpus comprised 475 Optopol .OPT files across two clinical sites: 387 at Site A (73 patients) and 88 at Site B (Queretaro); spanning three device models and four SOCT software versions, with 100% parse success across nine acquisition types. Cross-version compatibility was confirmed across SOCT versions 11.5.0-21.5.0, spanning approximately eight years of software development. The Zeiss Cirrus pipeline generated TID 1500 SRs for all 41 applicable studies (100%), yielding CMT 203-630 m and RNFL 53-123 m across a clinically representative range. The laterality-inference hypothesis was validated across 18 files from two device models and two software versions with 100% accuracy. Conclusions. Transducin provides the first publicly documented specification of the Optopol .OPT format and the first open-source multivendor pipeline generating SNOMED-CT coded DICOM Structured Reports from both Optopol REVO and Zeiss Cirrus devices, closing a gap explicitly confirmed by both manufacturers' own documentation. The code is available at https://github.com/oftalmos-org/transducin (Apache License 2.0).