A Clinical Study to Compare the Anti Hypertensive Benefits of Cilnidipine, Azilsartan in Type 2 DM Patients

Background

Hypertension accompanies type 2 diabetes mellitus increasing cardiovascular and renal risk and creating a need for effective, well-tolerated antihypertensive therapy. This study compared the short-term effects of cilnidipine and azilsartan in adults with T2DM and newly diagnosed hypertension. Methodology: In this open label randomized control trial, 61 subjects were administered Azilsartan 40mg once daily (n=30) and Cilnidipine 5mg once daily (n=31) for 3 months. The effects on blood pressure, glycemic parameters, lipid profile, high sensitivity C Reactive Protein (hs-CRP), renal parameters, Body Mass Index and quality of life parameters were evaluated.