Management of a Young Girl with Galloway-Mowat Syndrome: 4 Years on Peritoneal Dialysis

Introduction: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset steroid-resistant nephrotic syndrome, microcephaly, severe psychomotor retardation, and hiatus hernia. We report the case of an 8-year-old girl from a consanguineous family, diagnosed with GAMOS, who has been on continuous ambulatory peritoneal dialysis (CAPD) for 4 years. Case Presentation: The patient presented with microcephaly at birth and developed steroid-resistant nephrotic syndrome at 8 months of age; renal biopsy was consistent with focal segmental glomerulosclerosis (FSGS). Psychomotor and severe mental retardation were confirmed at 12 months. At 4 years of age, she was initiated on CAPD for end-stage renal disease (ESRD). Her clinical course has been marked by anuria, one episode of peritonitis over 24 months, and well- managed anemia with erythropoietin. However, genetic analysis has not yet been performed to confirm the diagnosis, and this remains a limitation of the present case report. Genetic testing is planned to confirm the diagnosis and enable accurate genetic counseling for the family. Discussion and Conclusion: This case highlights the feasibility and challenges of long-term peritoneal dialysis in children with syndromic nephropathies, particularly in resource-limited settings, and underscores the importance of a multidisciplinary approach including genetic counseling and consideration of renal transplantation.