Prevalence of high anti-A and/or anti-B antibody titres in donations collected from blood donors at the Regional Blood Center in Poznań

Introduction

High-titre anti-A and anti-B isoagglutinins represent an important challenge in low-titre group O whole blood (LTOWB) programmes. Data regarding donor-level prevalence and longitudinal variability of elevated isoagglutinin titres in Central European donor populations remain limited. Material and methods: A retrospective donor-level analysis was performed in 32,693 whole blood donors screened in 2019 at the Regional Blood Centre in Poznan. High-titre (HT) anti-A and/or anti-B antibodies were defined using an automated PK7300 screening strategy corresponding to a manual tube titre threshold of ≥1:128. Associations between HT positivity and donor characteristics were evaluated. Longitudinal analysis was performed in donors with repeated determinations.