University of Regensburg Publication Server
Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis
By Michael J. Stein, Claas Lendt, Fabian Bamberg and 22 others.
Abstract
Background
Insufficient physical activity is a leading global cause of premature mortality, yet how light-, moderate-, and vigorous-intensity activity differ in their associations with mortality and the implications of reallocating time across intensities remain unclear.
Methods
We prospectively analysed individually pooled baseline device-measured physical activity from 147,414 participants aged 40–74 years in the German National Cohort (NAKO) and UK Biobank, the largest pooled accelerometer dataset to date. Multivariable Cox models estimated hazard ratios (HR) and 95% confidence intervals (CI) for mortality across activity intensities and under time-reallocation models holding total active time constant.
