Comparative Statistical Analysis of Nitric Oxide and Adiponectin as Enhancers of Mesenchymal Stem Cell Therapy for Cardiac Regeneration

Heart diseases affect millions of lives every day. Additionally, the increasing age demographic of the US will cause healthcare prices to skyrocket. Life-threatening conditions can only be prevented using safe and effective treatments designed to mitigate and even reverse the effects of cardiomyopathy. These treatments must also be cost-effective so many can afford it. A simple, but powerful solution is MSCs. MSCs (Mesenchymal stem cells) are Mesoderm-derived stem cells which can rapidly adapt and differentiate to their environment. MSCs can be used as a potential target treatment for common and deadly conditions such as Myocardial Infarction. In addition, MSCs are versatile and can take in many enhancers to improve their heart rejuvenation capabilities. Therefore, to explore MSC’s true potential in Heart Rehabilitation, we must analyze the capabilities of multiple different enhancers to determine a minimal and cost-effective treatment for patients in need. Nitric Oxide and Adiponectin were compared in this study as enhancers of MSCs. Nitric Oxide is a common gas released in small amounts in the body while Adiponectin is a protein found in adipose cells responsible for beta oxidation (3,4). I hypothesized that Adiponectin would have a greater effect on the mice model than Nitric Oxide because Adiponectin is naturally derived. Although the results showed a greater benefit towards using Nitric Oxide, the differing baselines between both studies fail to confirm the result. Therefore, studying the difference between MCSs’ stemness enhancers requires similar controls and similar environment to reduce error. Although the benefit of these enhancers (Adiponectin and NO) is not fully optimized to have the greatest benefit, this paper serves to broaden the field of MSCs and their applications.