When inclusion is not enough: reconstructing physiological models from female trajectories

Physiological models are often built on populations that no longer accompany them, and female data are then read as deviations from those models. Most existing frameworks act on objects and categories already constituted. We propose an additional operation, applied one domain at a time: suspending inherited comparators; auditing the evidential record by disaggregating primary observations, measurement procedures, sampling frames, comparison structures and later interpretive layers; reconstructing variables and categories from female trajectories; generating competing models; and deferring between-sex comparison to a preregistered validation. The audit returns one of three verdicts, the most demanding requiring that primary descriptive research be reopened. Inclusion is not reconstruction: a research population can be almost entirely female while the hierarchy of its observations remains inherited. We describe a precedent in descriptive anatomy and apply the procedure to pain in lipedema. The frame is warranted only where it outperforms current models and alternative stratifications.