Abstract / Summary
Conventional medicine has primarily classified diseases according to affected organs, anatomical locations, and pathological characteristics. This paper proposes a new disease classification framework that incorporates the body’s reconstruction capacity and its functional state as an additional perspective. In my previous study, rapid systemic immune and regenerative responses following localized mechanical stimulation were observed through plasma and exosomal proteomics and flow cytometry. Based on these observations, the Emergency Regenerative Defense Program (ERDP) was developed as a model of a pre-stored reserve-dependent, high-output reconstruction program activated when a specific stimulation threshold is exceeded. Under normal conditions, the body remains in a low-output repair mode, and ERDP activation requires specific conditions. This paper classifies reconstruction-related dysfunction into four types: Type I, failure of ERDP activation; Type II, incomplete reconstruction; Type III, deficiency in ERDP activation capacity; and Type IV, dysregulation of reconstruction control. Furthermore, potential bottlenecks that interfere with reconstruction are classified into Stages 0–3 according to the phase at which they occur. Cancer is examined in particular as a condition in which certain mechanisms normally involved in reconstruction become dissociated from integrated regulatory control. Its underlying structure and potential implications for future research are discussed in detail. This classification framework introduces an additional perspective to conventional disease classification and may contribute to advances in disease understanding, therapeutic strategies, regenerative medicine, and cancer research. Call for Collaboration: Researchers and institutions interested in validating this classification framework, independently reproducing ERDP responses, or comparing reconstruction states across different diseases are invited to collaborate. ERDP Research Website: https://takereshin.wixsite.com/website-1 Foundational Study: A Systems-Level Immune-Regenerative Response Induced by Localized Mechanical Stimulation in Humans DOI: https://doi.org/10.5281/zenodo.16884465