Clinicopathological spectrum and oxford mest-c correlates of iga nephropathy: A retrospective kidney biopsy study

Background

IgA nephropathy (IgAN) varies considerably in clinical presentation and renal biopsy morphology. Indian center-specific data remain important because biopsy practices and disease severity differ across settings. The study is designed to describe the biopsy proportion, clinical profile, immunofluorescence findings, Oxford MEST-C distribution, and selected clinicopathological associations in IgAN. Materials and Methods: This retrospective study reviewed native kidney biopsies diagnosed as IgAN at CPath Labs, Hyderabad, from May 2016 to September 2025. Seventy-two IgAN cases were identified among 1,608 native kidney biopsies. Demographic, laboratory, immunofluorescence, and histopathological data were extracted from existing records. Complete MEST-C scores were available in 59 cases. Mann-Whitney U or Kruskal-Wallis tests were used for serum creatinine comparisons, and chi-square or Fisher exact tests for categorical associations. A two-sided p<0.05 was considered significant.