Spectrophotometric estimation of artemether & lumefantrine in pharmaceutical formulation by using mean centering of ratio spectra & h- point standard addition method

Background

Artemether–lumefantrine is a World Health Organization-recommended artemisinin-based combination therapy for uncomplicated falciparum malaria, marketed as a fixed-dose combination in a 1:6 ratio. Quality-control estimation of both components in combined dosage forms conventionally relies on chromatographic methods that are costly, time-consuming, and solvent-intensive.

Objective