Abstract / Summary
GC–MS analysis revealed three chromatographic peaks in Dhanwantharam Gulika and eighteen in Krimisodhini Gulika. These yielded three and eighteen best-supported tentative assignments, respectively, together with up to nine and fifty-four total library candidates when alternative spectral matches were included. Dhanwantharam Gulika was predominantly characterised by monoterpenoid/borneol derivatives, which accounted for approximately 93.17% of the total peak area, whereas Krimisodhini Gulika exhibited a diverse phytochemical profile comprising terpenoids, long-chain fatty acids, phenyl propanoids, lactones, esters, and nitrogen-containing compounds, with n-hexadecanoic acid representing 38.18% of the peak area. Both formulations exhibited appreciable antimicrobial activity against the tested microorganisms. Molecular docking against gastric lipase produced a best Glide XP docking score of −4.074 kcal/mol, while the most favourable MM-GBSA binding free energy reached −31.57 kcal/mol among the screened constituents. These computational results indicate moderate predicted ligand–protein interactions and should be considered preliminary, requiring experimental validation.