Insulin Analogues (Insulin Detemir and Insulin Aspart) Versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in Basal Bolus Therapy for Patients with Type-I Diabetes Mellitus

Objective

To compare the effect of Insulin analogues (Insulin Detemir and Insulin Aspart) versus Traditional Human Insulins (NPH Insulin Regular Human Insulin) in basal bolus therapy for patients with Type-I Diabetes Mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jun 2021 to Jun 2022. Methodology: The sample population comprised of 125 type I diabetes mellitus patients which were diagnosed in our department and managed. Patients were divided into two Groups via lottery method. Group A received the Insulin analogues (Insulin Detemir and Insulin Aspart) while Group B received the Human Insulins (NPH Insulin Regular Human Insulin). Glycosylated hemoglobin, weight gain, hypoglycemic episodes and compliance were compared in both Groups at the end of three months.