Comparison of Oral Allopurinol with Intralesional Meglumine Antimoniate in Treatment of Cutaneous Leishmaniasis

Objective

To establish efficacy of Allopurinol in Cutaneous Leishmaniasis. Study Design: Quasi experimental study. Place and Duration of study: Department of Dermatology, Combined Military Hospital, Rawalpindi Pakistan, from Apr to Sep 2024. Methodology: After approval from hospital ethical committee 60 patients of age ranging from 20 – 50 years, who fulfilled the inclusion criteria were enrolled in this study. Duration of study was 6 months. Patients were randomly allocated to Group-1 and Group-2 and each group had 30 participants. Group-1 patients were given oral Allopurinol 10-15mg/kg in 2-3 divided doses for 8 weeks. Group-2 patients were given 1-2ml intralesional Meglumine Antimoniate according to lesion size for 8 weeks. Lesions were assessed at the end of treatment by palpation to measure the induration and by ruler to measure the size of lesion. The drug was considered efficacious if there was 75 percent reduction in size and induration of lesion.