Comparison of Silodosin and Tamsulosin in Medical Expulsive Therapy of Distal Ureteric Calculi

Objective

To carry out comparative analysis of Silodosin and Tamsulosin in medical expulsive therapy of distal ureteric calculi, in terms of stone clearance rate and stone expulsion time. Study Design: Randomized clinical trial (clinicaltrials.gov - NCT05790902). Place and Duration of Study: Urology OPD, Armed Forces Institute of Urology, Rawalpindi Pakistan, from Sep 2022 to Feb 2023. Methodology: A total of 142 cases with unilateral Distal Ureteric Calculi (DUC) of <8 mm in size were enrolled and allocated randomly into two groups, each having 71 cases. Patients of Group-A and Group-B used 8 mg of Silodosin and 0.4 mg of Tamsulosin daily respectively. They were followed weekly until stone passage/four weeks, to document Stone Clearance Rate (SCR), no of Ureteric Colic Episodes (UCE), Stone Expulsion Time (SET), Postural Hypotension (PH) and Abnormal Ejaculation (AE).