Hantavirus Outbreak on MV Hondius Cruise Ship: India’s Port Health Preparedness – A One Health Perspective

Abstract The MV Hondius outbreak, reported in May 2026, is among the first large multinational hantavirus clusters linked to cruise ship travel. By July 2, 2026, when the outbreak was declared over, 13 cases (12 laboratory-confirmed and one probable) and three deaths had been reported, with contact tracing involving 33 countries and territories; no confirmed cases were reported in India. The identified Andes virus strain is notable for limited person-to-person transmission. This viewpoint is an interpretation of the outbreak using publicly available reports, scientific literature, and official communications from health agencies within a One Health framework, focusing on implications for India’s port health preparedness. The outbreak highlights how ecological exposure, international mobility, and a confined maritime environment can facilitate disease spread. India’s port health infrastructure includes pre-arrival vessel risk assessment, passenger thermal scanning, and contingency plans aligned with the International Health Regulations (IHR) 2005. Although hantavirus strains identified in India are not associated with person-to-person transmission, existing seroprevalence data support the need for continued surveillance. Strengthening a One Health approach integrating human, animal, and environmental surveillance is essential for future maritime outbreak preparedness. Trained port health personnel, improved diagnostics, and effective public communication remain essential.