Pharmaceutics
Preparation of Excipient-Free Molnupiravir Microparticles for Pulmonary Drug Delivery and Process Evaluation via Machine Learning
By Juncheng Hu, Yucheng Huang, Jiahao Luo and 8 others.
Abstract
Background/Objective: Molnupiravir (EIDD-2801) was originally designed to treat influenza A virus and showed broad-spectrum antiviral activity, including against influenza virus, Ebola virus, coronavirus and other viruses.
Methods
In this study, molnupiravir microparticles were firstly prepared by spray freeze-drying (SFD) and jet milling (JM) methods. Meanwhile, machine learning methodology was applied to evaluate the influence of process parameters such as feeding rate, concentration, and nebulization pressure on powder properties.
