Scutellarin Alleviates Pulmonary Hypertension by Inhibiting the NF-κB/NLRP3 Signaling Pathway to Suppress Inflammation and Pyroptosis

Background

Pulmonary arterial hypertension (PAH) is a progressive fatal cardiovascular disorder characterized by pulmonary vascular remodeling, elevated pulmonary vascular resistance and right heart failure, mainly driven by chronic inflammation and aberrant cell death. Scutellarin (SCU), a natural flavonoid with anti-inflammatory and vasculoprotective properties, exhibits unknown therapeutic effects and mechanisms against PAH. This study aimed to explore the therapeutic potential of SCU for PAH and to clarify its underlying mechanism targeting NF-κB/NLRP3 signaling-mediated inflammation and pyroptosis.