Protective Effects of Total Alkaloids of Rhizoma Corydalis Against Neuronal Ferroptosis Through a PPARγ-Dependent Mechanism in Diabetes-Associated Cognitive Impairment

Objectives

Previous studies from our laboratory have established a strong correlation between diabetes-associated cognitive impairment (DACI) and neuronal ferroptosis. This study aimed to elucidate the therapeutic mechanisms of total alkaloids of rhizoma corydalis (TAC) in mitigating DACI, with a specific focus on its modulation of neuronal ferroptosis via the PPARγ pathway.