Nutrients
Sex Differences in Hepatic VLDLR Response to Protein Restriction and Its Relationship with Hepatic Lipid Accumulation
By Jiuxiang CAO, Hiromu Morimoto and Asako Takenaka.
Abstract
Background/Objectives: The very low-density lipoprotein receptor (VLDLR) mediates VLDL uptake in peripheral tissues. This study investigated sex differences in hepatic VLDLR response to protein restriction and its relationship with hepatic lipid accumulation.
Methods
Male and female wild-type (WT) and Vldlr knockout (KO) mice were fed control (20% protein) or low-protein (2% protein) diets for 20 days. Hepatic VLDLR expression and triglyceride levels were determined, followed by RNA sequencing and Gene Ontology (GO) analysis.
