Metabolites
A Shift in the Plasma 7-Oxysterol Redox Axis in Colorectal Cancer
By Muhammad Kamran, Irundika H.K. Dias, Akinfemi Ayobami Akingboye and 1 others.
Abstract
Background/Objectives: Colorectal cancer (CRC) involves metabolic reprogramming, including altered cholesterol handling and redox homeostasis. Oxysterols link lipid metabolism with redox and immune regulation, but whether defined oxysterol redox systems are perturbed in the circulation is unclear. One such system is the 7-ketocholesterol (7-KC)/7β-hydroxycholesterol (7β-OHC) couple, interconverted by 11β-hydroxysteroid dehydrogenases (HSD11B1 and HSD11B2).
