Pooled Follicular-Fluid Melatonin Under Standardized Supplementation in IVF-ICSI Cycles: Associations with Clinical Ovarian Response Phenotypes and Exploratory Embryological Outcomes: A Prospective Observational Study

Background

Melatonin concentrations in follicular fluid exceed serum levels, suggesting local ovarian accumulation and a potential role in the follicular microenvironment. Previous studies reporting associations between intrafollicular melatonin and IVF outcomes have largely relied on dominant-follicle sampling. This study evaluated pooled follicular-fluid melatonin concentrations across clinical ovarian-response phenotypes in women undergoing standardized melatonin-supplemented IVF-ICSI cycles.