DNA Methylation Patterns Between Serous Uterine and Ovarian Carcinomas Indicate Shared Markers with Fallopian Tube Epithelium and Distinctions Consistent with Histopathology

Background/Objectives: Uterine serous carcinoma (USC) is a deadly form of Type II endometrial cancer of rising incidence in the USA. It is currently thought to originate in the uterus, but emerging evidence suggests USC etiology is more complex and may involve the fallopian tube. DNA methylation is an inheritable suppressive epigenetic marker that can differentiate cellular origins, so we opted to perform a study comparing DNA methylation of USC to the fallopian tube and uterus.