Method Comparison of Three Automated D-Dimer Assays

Background and Objective: D-dimer results differ across analytical platforms, which may affect their clinical interpretation. This study aimed to compare the analytical agreement and threshold-based classification of three routinely used D-dimer analyzers.

Methods

Of 150 consecutive residual citrated plasma specimens, 81 patient specimens with valid results on the Sysmex CS-2500, Tokra Novae MTI, and VIDAS 3 analyzers were included. Agreement was assessed using the intraclass correlation coefficient, Passing–Bablok regression, Bland–Altman analysis, and classification concordance at the fixed (500 ng/mL FEU) and age-adjusted thresholds. VIDAS 3 served solely as the comparator method.