Cosmetics
Niacinamide, Prebiotic, and Postbiotic Emollient Versus Urea 10% Cream for EGFR Inhibitor-Induced Xerosis and Pruritus: A Double-Blind Randomized Trial
By Daniele Omar Traini, Gerardo Palmisano, Alessandro Di Stefani and 3 others.
Abstract
Background
Xerosis and pruritus are frequent and burdensome adverse effects of epidermal growth factor receptor inhibitors (EGFRIs), reflecting a therapy-induced disruption of epidermal barrier integrity and keratinocyte homeostasis. While urea-based emollients are widely recommended, emerging dermocosmetic strategies targeting barrier repair and microbiome modulation may offer alternative or complementary benefits.