Anticancer Effects of Genistein and Its Interaction with Temozolomide in Human Melanoma, Neuroblastoma and Glioblastoma Cells

(1)

Background

Melanoma, glioblastoma, and neuroblastoma have distinct cellular origins, biological characteristics, and clinical behavior. Although these tumors differ in their origins, they exhibit aggressive biological features and may develop treatment resistance. New therapeutic options are constantly being sought. This study aimed to evaluate the anticancer potential of genistein, a soy-derived isoflavone, and investigate the pharmacodynamic interactions between genistein and temozolomide in human melanoma, neuroblastoma, and glioblastoma cell lines. (2)