Age-Stratified Integrative Transcriptomic Analysis Reveals a Conserved Fibrotic Core and Distinct Molecular Signatures in Hypertrophic Cardiomyopathy

Background

Hypertrophic cardiomyopathy (HCM) exhibits clinical heterogeneity and age-related penetrance, yet its molecular basis across adulthood remains incompletely understood. This study aimed to characterize age-dependent transcriptomic signatures and identify conserved molecular features across adult HCM.

Methods