Cancers
WBRT Plus SIB in Patients with Brain Metastases: Association with Longer Overall Survival and Safety Outcomes in a Single-Center Retrospective Analysis
By Zibo Tang, Guixiang Liao and Juan Fan.
Abstract
Objective
To compare the efficacy, survival benefits, and safety of whole-brain radiotherapy (WBRT) alone versus WBRT combined with simultaneous integrated boost (WBRT+SIB) for patients with brain metastases.
Methods
A total of 100 patients treated from 2017 to 2022 were retrospectively analyzed. Tumor response was assessed per RECIST 1.1. Survival differences were compared using the Kaplan–Meier method and log-rank test. Multivariate Cox regression and subgroup analyses were performed to evaluate the prognostic value and stability of WBRT+SIB.
