Developing a Conceptual Framework: Integrating Tumour, Macroenvironment and Resource (TMR) as a Composite Determinant of Ovarian Cancer Outcome in Diverse Resource Settings

Background

Ovarian cancer (OC) poses an escalating global health burden, with marked disparities in incidence, mortality, and survivorship. Social, psychological, and structural determinants, including deprivation, stigma, and access to specialist care, may influence outcomes but are not well-represented in existing models of cancer care. We introduce the Tumour, Macroenvironment and Resource (TMR) framework, a novel conceptual model exploring interactions among tumour biology, social determinants, and healthcare resources in OC survivorship and care.