Cancers
O-GlcNAcylated TCF4 Drives Ferroptosis Resistance and Tumor-Associated Macrophage Infiltration to Promote Colorectal Cancer Liver Metastasis
By Han Yang, Jinhao Yu, Dong Hou and 6 others.
Abstract
Background
Colorectal cancer liver metastasis (CRLM) remains a major cause of mortality in colorectal cancer (CRC), while the upstream molecular mechanisms linking tumor cell adaptation and immune microenvironment remodeling remain poorly understood.
Methods
By integrating single-cell RNA sequencing, multi-omics analysis, clinical cohorts, and functional experiments, we investigated the role and mechanism of TCF4 post-translational modification in CRLM progression.