Cancers
SPINT2 Is Associated with Dual-Phenotype Hepatocellular Carcinoma and Aggressive Tumor Features
By Jie Zhang, Minjun Li, Taixin Yang and 5 others.
Abstract
Background
Hepatocellular carcinoma (HCC) heterogeneity, particularly the presence of tumor cells co-expressing hepatocytic and cholangiocytic markers, contributes to therapeutic resistance and poor prognosis, yet its molecular correlates remain incompletely understood. This study aimed to characterize dual-phenotype HCC (DPHCC) and investigate the association and functional relevance of SPINT2 in tumor progression.
