Latent Multidimensional Organization of White Matter Microstructural Aging: A Generative Adversarial Network Disentanglement Study in a Clinically Defined Reference Cohort

Background

White matter (WM) aging is commonly characterized as a largely unitary process of progressive microstructural decline, yet substantial interindividual variation suggests that this view may obscure distinct biological dimensions. Whether WM aging retains a multidimensional organization after minimizing variation attributable to overt clinical pathology remains unknown.