Effects of Second-Generation Long-Acting Injectable Antipsychotics on Brain Structure in Schizophrenia: A Systematic Review of Neuroimaging Studies

Background/Objectives: Second-generation long-acting injectable antipsychotics (SGA-LAIs) are increasingly used to improve adherence and prevent relapse in patients suffering from schizophrenia. Beyond clinical efficacy, growing attention is being paid to their potential impact on brain structure. This systematic review aims to synthesize available evidence from neuroimaging studies investigating the effects of SGA-LAIs on grey matter (GM) and white matter (WM) in individuals with schizophrenia.